Thank you for reaching out to us. Yes you can do this with image element in content builder. First add an image element and turn on the Link option:
Then in URL field input the URL of the image you want to show in lightbox:
Now give a class to your image element e.g
Finally add a Text or Classic Raw Content element with the Lightbox shortcode:
Repeat the above steps for other images expect adding the Lightbox shortcode multiple times, just add it once. To learn more about Lightbox shortcode please see https://theme.co/apex/forum/t/shortcodes-lightbox/165
Hope this helps!